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Levels of cell-free DNA do not impact ctDNA detection in patients with CRC

January 2023 There is increasing evidence to support the use of circulating tumour DNA (ctDNA) as a biomarker to detect minimal residual disease (MRD) in colorectal cancer (CRC). Biomarker: a molecule that can be found in the the body (e.g. in the blood or tissues) that can be used as a sign of a normal or abnormal pro...

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Trifluridine plus tipiracil and bevacizumab is a new standard of care for refractory metastatic colorectal cancer

January 2023 Findings from the phase III SUNLIGHT trial were presented at the 2023 ASCO Gastrointestinal Cancers Symposium, demonstrating that the combination of bevacizumab (commercial name: Avastin®) plus trifluridine/tipiracil (commercial name: Lonsurf®) promoted an improvement in overall survival and progression-free su...

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The CheckMate 8HW study: A study of nivolumab, nivolumab plus ipilimumab, or investigator’s choice chemotherapy for the treatment of participants with deficient mismatch repair (dMMR) / microsatellite instability high (MSI-H) metastatic colorectal cancer (mCRC)

Locations: BC, AB, ON, QC Status: currently recruiting Trial description: The purpose of this study is to compare the clinical benefits and compare the efficacy (how well the drug works), harmlessness (safety), and tolerability of the immunotherapy drug nivolumab in combination with the immunotherapy drug ipilimumab OR b...

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Exercise during chemo may help beat the treatment’s debilitating effects

November 2022 A new study involving patients with different cancer types who were undergoing chemotherapy found that exercising during treatment helped patients overcome the treatment’s debilitating effects and speed up the return of function following chemotherapy. While previous research has shown that exercise can bene...

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Differences in the gut microbiome by physical activity and BMI among colorectal cancer patients

November 2022 To better understand the role of the gut microbiome in colorectal cancer (CRC) development, a new study investigated associations between physical activity, body mass index (BMI), gut microbiome diversity and different abundances of gut microbes among CRC patients. The study, published in the American Journa...

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