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HER2 Therapies for Patients with mCRC

Image source: https://www.whathealth.com/breastcancer/her2receptor.html May 2022 HER2 (human epidermal growth factor receptor 2) is a protein receptor found in all human cells and is responsible for controlling cell growth and repair. When the HER2 gene acquires mutations which cause it to be amplified or overexpressed in th...

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Overall survival associated with Pembrolizumab (Keytruda) vs. Chemotherapy in MSI-H/dMMR mCRC

May 2022 The KEYNOTE-177 trial is a landmark study in colorectal cancer treatment that evaluated the efficacy and safety of the immunotherapy drug, pembrolizumab (Keytruda), compared to standard of care chemotherapy for patients with microsatellite instability high (MSI-H), mismatch repair deficient (dMMR) metastatic colo...

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Alcohol intake and risk of alcohol-related cancer

A new study from Australia found that heavy drinking in early adulthood may increase the risk for alcohol-related cancers, including colorectal cancer (CRC), even after drinking decreases or stops entirely in middle age. Alcohol is a known risk factor for CRC – the 2018 World Cancer Research Fund and American Institute f...

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Associations between unprocessed red meat and processed meat with risk of recurrence and mortality in patients with stage III colon cancer

A study published in JAMA Network Open investigated whether consumption of unprocessed red meat or processed meats such as bacon, ham, or smoked meats after a colon cancer diagnosis were associated with a higher risk of recurrence and death. Both the American Cancer Society and the American Institute for Cancer Research reco...

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Can weight loss in adulthood reduce the risk of developing colorectal adenomas?

While obesity is a known risk factor for colorectal cancer (CRC), the impact of weight change on the development of adenomas, a type of precancerous polyp, is not well understood. A new study published in JNCI Cancer Spectrum found that weight loss among adults, particularly for those who are overweight or obese, may reduce ...

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