Phase 3 Trial Finds that a Structured Exercise Program Significantly Improves Survival and Reduces Recurrence in Colorectal Cancer Patients

A randomized phase 3 trial (CHALLENGE, CO.21) conducted by the Canadian Cancer Trials Group found that a 3-year structured exercise program following surgery and chemotherapy significantly improved outcomes for patients with stage III and high-risk stage II colorectal cancer. Compared to patients who only received health education materials, those in the exercise group experienced better disease-free survival (80% vs. 74% at 5 years), overall survival (90% vs. 83% at 8 years), and physical functioning (e.g. a person’s ability to carry out daily activities). The structured program, guided by physical activity consultants and tailored to individual preferences, reduced the risk of cancer recurrence by 28% and death by 37%. While some patients experienced mild musculoskeletal side effects, the program was generally safe. These findings, presented ahead of ASCO 2025, highlight the role of supervised exercise in improving long-term cancer outcomes and quality of life.