COVID-19 and Colorectal Cancer Get The Facts

Gut bacteria found to modulate response to cancer immunotherapy

Previous data have shown that certain species of intestinal bacteria not only help to regulate the immune function of the entire body, but also optimize the therapeutic effect of cancer immunotherapy drugs such as anti-PD-1/PD-L1 and anti-CTLA-4 drugs. The exact mechanism of how this works on the molecular level, however, has remained uncertain.

A recent study published in Science isolated three bacterial species that were shown to significantly enhanced the efficacy of immunotherapy drugs in mouse models of cancer. One intestinal bacterium in particular, Bifidobacterium psudolongum, was found to enhance immunotherapy response through the production of a substance (metabolite) called inosine. Due to decreased functioning of the gut barrier (the property of the intestinal lining to contain bowel contents while preserving the ability to absorb nutrients) during immunotherapy treatment, inosine was found to pass through the intestinal barrier and activate anti-tumour T cells, a specialized type of immune cell. This enabled the body to mount a more effective immune response and enhance the overall effectiveness of the immunotherapy treatment.The study findings identify a novel microbial metabolite – immune pathway that may be used in the future to develop adjuvant therapies that may be given in addition to immunotherapy to maximize effectiveness.

Click to read the full article:

https://science.sciencemag.org/content/early/2020/08/12/science.abc3421

 

Welcoming Our Newest CCC Ambassador, Jesse Fishman!

Jesse Fishman is a 17-year-old hockey player, currently playing for the Ki [...]

READ MORE

Do young diabetes patients need early CRC screening?

12 August 2020 Recent findings from a Swedish cohort study found that p [...]

READ MORE

Cancer Recurrence amid COVID-19: Robin’s Story

It was the day of the lockdown. My family doctor called. “The colorectal c [...]

READ MORE

Never Too Young Survey Launch

Fill out the survey! The world was shocked late last week as we learned a [...]

READ MORE

Your Seasonal Guide to Cancer-Fighting Foods

As we transition into autumn, take a moment to appreciate the seasonal pro [...]

READ MORE

Psychosocial support for patients with cancer during COVID-19

The COVID-19 pandemic has presented countless new challenges in cancer car [...]

READ MORE

COVID-19 NEWSLETTER

The COVID-19 pandemic situation is constantly evolving. Canada is slowly r [...]

READ MORE

CRC with peritoneal metastases: CRS-HIPEC refinements

Results of several new studies provide important perspectives on the use o [...]

READ MORE

Four actionable targets for metastatic colorectal cancer

In the past two years, findings from important clinical trials are shaping [...]

READ MORE

Patient Group Pathway Model to Accessing Cancer Clinical Trials and RWE Conference

Hold the Date! On behalf of Colorectal Cancer Canada (CCC), you are cordi [...]

READ MORE

Lynch Syndrome, Explained

What is Lynch Syndrome? Lynch syndrome is a genetically inherited conditi [...]

READ MORE

COVID-19 PATIENT SURVEY REPORT

Coronavirus has taken the world by storm since the beginning of 2020, and [...]

READ MORE

PUSH FOR YOUR TUSH VIRTUAL EVENT 2020

To ensure the health and safety of our participants, volunteers, staff and [...]

READ MORE

Gastrointestinal Highlights from last month’s ASCO 2020 Meeting

The American Society of Clinical Oncology (ASCO) held its annual meeting a [...]

READ MORE

How is colorectal cancer care changing in the era of COVID-19?

In just a few months, coronavirus (COVID-19) has transformed our lives. De [...]

READ MORE

Meatless for CRC prevention

It has been known for millennia that what we eat can be powerful medicine [...]

READ MORE

Immunotherapy treatment proves to be superior to chemotherapy for a specific subset of patients with mCRC

The last few decades have seen important advances in colorectal cancer tre [...]

READ MORE

Push For Your Tush volunteers spread the word

Co-leads of Push For Your Tush Ottawa share their connection to the cause [...]

READ MORE

2,700 VISITORS PASS THROUGH GIANT COLON TOUR AT THE SHERBROOKE HALF MARATHON

The Centre de recherche of the Centre hospitalier universitaire de Sherbro [...]

READ MORE

Colorectal cancer screening in Ontario is changing to the FIT

On June 24, 2019, colorectal cancer screening in Ontario is changing to th [...]

READ MORE

Remembering the “Father of Heredity Cancer” Dr. Henry Lynch

Today we remember Dr. Henry Lynch, esteemed researcher and father of hered [...]

READ MORE

Kicking cancer’s ass on the golf course

On Tuesday, July 16, Colorectal Cancer Canada (CCC) held our third annual [...]

READ MORE

Increasing rates of colon & rectal cancers in young people

Researchers with the World Health Organization confirm increased rates of [...]

READ MORE

CCC attends Early Age Onset Colorectal Cancer Summit in New York City

Last Thursday and Friday, Morgan Kennedy, CCC’s Never Too Young Program Ma [...]

READ MORE

Publication: Clinically meaningful survival benefit in refractory mCRC

Colorectal Cancer Canada (CCC) is proud to announce the publication of the [...]

READ MORE

Giant Colon visits University of Montreal Hospital Centre

Today, the Giant Colon Tour stopped at the University of Montreal Hospital [...]

READ MORE

CCC’s PUSH FOR YOUR TUSH SPARKS PARTNERSHIP WITH THE TORONTO PROFESSIONAL FIRE FIGHTERS ASSOCIATION

Most people do not know that cancer is the number one cause of death among [...]

READ MORE

March is Colorectal Cancer Awareness Month

March is Colorectal Cancer Awareness Month! Colorectal cancer may touch yo [...]

READ MORE

Sponsors