OUR 6th CLINICAL TRIALS CONFERENCE IS HAPPENING ON NOV 8 & 9 2022. CLICK HERE TO REGISTER TODAY

Understanding early-onset colorectal cancer: why are cases on the rise?

Chadwick Boseman’s death from colorectal cancer (CRC) at age 43 was a shock to many, but it has helped to bring the difficult issue of early-onset CRC to the forefront of public attention. According to the most recent CRC statistics, the incidence of new CRC cases among adults below the age of 50 continues to increase by about 2% per year. In comparison, new CRC cases were on the decline for people aged 50-64, though since 2016 the rates have been increasing by 1% per year.

About 1 in 5 younger patients with CRC have a genetic predisposition to the disease, though only about half of them have a family history of the disease that actually exhibits the genetic mutation. This highlights the importance of genetic testing among all young patients to help to protect their families. Other factors such as obesity, changes in the gut bacteria from antibiotic use, diets rich in sugar, fat, red meat and alcohol, and decreased physical activity and exercise have all been hypothesized as potential drivers of CRC incidence in young adults.

In young adults diagnosed with CRC, cancer tends to be located closer to the rectum, resulting in rectal bleeding. However, younger patients may sometimes go much longer before being diagnosed because they either ignore their symptoms or, if they do talk about their symptom with their doctor, CRC is not even considered as a possible cause. Both patients and doctors need to be educated about this growing concern so that no signs or symptoms are missed.

Another issue that was brought to the surface with Chadwick Boseman’s death was the question of why Black populations experience greater CRC incidence and mortality rates compared to other racial groups. Disparities in health, such as differential access to quality healthcare including cancer treatment, screening, follow-ups and referrals to cancer specialists, as well as diet, obesity and socioeconomic factors are likely to have a significant role in how CRC impacts Black populations. A recent retrospective study published in JAMA Network Open examined data from 16,382 adult patients from the California Cancer Registry and found that Black patients were the least likely to receive chemotherapy or surgery to remove CRC liver metastases, and had a 17% higher chance of death compared to White patients. The researchers found that among patients who underwent liver resection for metastases, there was no difference in survival between Black and White patients. This suggests that if Black patients were able to access life-saving therapies such as liver resection at the right time, they would not experience the increased number of unnecessary deaths due to the disease.

Colorectal cancer is highly treatable when it is caught early, which depends on screening when you are healthy and well. Once symptoms such as rectal bleeding, change in bowel habits or abdominal pain begin to emerge, evaluation by a healthcare professional is necessary. The American Cancer Society recently changed their CRC screening guidelines to take into account the rising incidence of early-onset disease and recommends that all people at normal risk begin screening at 45 years instead of 50. Screening is typically performed with a routine colonoscopy or through fecal immunochemical testing. Each test has its advantages and disadvantages, and the hope is that every individual will adhere to at least one form of screening.

Understanding ulcerative colitis: a risk factor for colorectal cancer

Ulcerative colitis is a chronic inflammatory bowel disease that affect [...]

READ MORE

Understanding Crohn’s disease: a risk factor for colorectal cancer

Crohn’s disease is a chronic (long-term) inflammatory disease that can [...]

READ MORE

Q&A with Dr. Brandon Sheffield, Pathologist

In this Q&A, Dr. Brandon Sheffield, Pathologist with the William O [...]

READ MORE

Q&A with Suzanne Zwicker, clinical pharmacist

In this Q&A, Suzanne Zwicker, Clinical Pharmacist on the National [...]

READ MORE

ESMO World Congress on Gastrointestinal Cancer 2022

July 2022 The annual ESMO World Congress on Gastrointestinal (GI) C [...]

READ MORE

Regional Therapy for Colorectal Cancer Liver Metastases

July 2022 Patients who have colorectal cancer that has spread to th [...]

READ MORE

Minimal Residual Disease (MRD) and CRC

June 2022 Minimal residual disease (MRD) is a term that refers to cance [...]

READ MORE

ASCO 2022

June 2022. Key Updates from ASCO 2022 1. Immunotherapy treatment res [...]

READ MORE

HER2 Therapies for Patients with mCRC

May 2022. Image source: https://www.whathealth.com/breastcancer/her2rec [...]

READ MORE

Overall survival associated with Pembrolizumab (Keytruda) vs. Chemotherapy in MSI-H/dMMR mCRC

May 2022 The KEYNOTE-177 trial is a landmark study in colorectal ca [...]

READ MORE

Alcohol intake and risk of alcohol-related cancer

April 2022. A new study from Australia found that heavy drinking in [...]

READ MORE

Associations between unprocessed red meat and processed meat with risk of recurrence and mortality in patients with stage III colon cancer

April 2022. A study published in JAMA Network Open investigated whe [...]

READ MORE

Can weight loss in adulthood reduce the risk of developing colorectal adenomas?

March 2022. While obesity is a known risk factor for colorectal can [...]

READ MORE

The emotional impact of a colorectal cancer diagnosis

https://youtu.be/-Oi2jBJDUNc February 2022. Join Patient Support Spe [...]

READ MORE

ASCO GI 2022: Trial evaluating immunotherapy in neoadjuvant setting for the treatment of locally advanced rectal cancer

January 2022 Total neoadjuvant therapy (TNT) is a standard approach [...]

READ MORE

ASCO GI 2022: Key considerations about oxaliplatin for the treatment of mCRC

January 2022 Oxaliplatin is an important intravenous chemotherapy d [...]

READ MORE

Webinar: Supporting individuals awaiting an ostomy and those living with one

January 2022. Laura Ferguson, a current ileostomy patient, and Karen Br [...]

READ MORE

Webinar: Intimacy and Cancer

Join Chana, our Patient Support Specialist, as she sits down to a cand [...]

READ MORE

Left Vs. Right Sided Colorectal Tumors: A Clinical Presentation by Dr. Scott Berry

Join Dr. Scott Berry, Professor & Department Head, Department of O [...]

READ MORE

Ask a Doctor : Q&A on Radiotherapy

Left: Laura A. Dawson, MD, FRCPC, Princess Margaret Cancer Centre/Univ [...]

READ MORE

FDA clears new drug application for CAR-T cell therapy for the treatment of solid tumours

This month, the Food and Drug Administration (FDA) cleared an investig [...]

READ MORE

Update on the role of low-dose aspirin in colorectal cancer prevention

  In 2016, the United States Preventive Services Task Force (U [...]

READ MORE

Interview: Jason Abramovitch

In 2020, Jason was diagnosed with stage 3b colorectal cancer at age 36. In [...]

READ MORE

Living with LARS: Naturopathy

Dr. Megan Bernard, naturopathic doctor, discusses a variety of tips and su [...]

READ MORE

Living with LARS: Nutrition

Nutritionist Jill Haverstock discusses a variety of tips and suggestions t [...]

READ MORE

Cancer Screening in Canada: Interview with Dr. Mel Borins

Dr. Mel Borins is a family practitioner based in Toronto, Ontario. He crea [...]

READ MORE

Interview: Jason from Man Up to Cancer

Jason Abramovitch is an early age onset stage 3b colon cancer survivor who [...]

READ MORE

Acupressure and Auricular Therapy for Symptom Management

On December 3rd 2021, Physiotherapist Thi Tran gave a compelling session o [...]

READ MORE

Underrepresentation in cancer clinical trials

November 2021 Findings from a recent study published in JAMA Networ [...]

READ MORE

First-line nivolumab plus low-dose ipilimumab for MSI-high/MMR-deficient mCRC

November 2021 Findings from phase II of the CheckMate-142 trial sho [...]

READ MORE

Highlights from the phase III EPOCH trial

The EPOCH trial is the first phase III international study evaluating the [...]

READ MORE

Impact of tumour vaccine on increasing anti-cancer response

Immunotherapy has revolutionized the way cancer is treated by boosting [...]

READ MORE

ESMO 2021 Congress: CRC highlights

Colorectal (CRC) cancer screening and diagnosis during the COVID-19 pa [...]

READ MORE

Antibiotic use and colon cancer: more evidence of link

A Swedish population study published this month in the Journal of the [...]

READ MORE

Clinical implications of the ongoing GALAXY trial

Adjuvant (post-surgical) chemotherapy is useful in reducing the risk o [...]

READ MORE

Developing a better fecal immunochemical test (FIT) for colon cancer screening

The fecal immunochemical test (FIT) is a widely used colorectal cancer [...]

READ MORE

Colon cancer data reinforce need to reduce unnecessary antibiotic use

New findings from a study presented at the European Society for Medica [...]

READ MORE

Red meat consumption may promote DNA damage-associated mutations in patients with colorectal cancer

While many different risk factors for colorectal cancer (CRC) have bee [...]

READ MORE

Is it time for universal genetic testing in colorectal cancer?

Findings from a recent study show that multigene panel testing of patients [...]

READ MORE

USPSTF final recommendation on CRC screening: 45 is the new 50

The final recommendation from the United States Preventive Services Ta [...]

READ MORE

Periodontal disease can be a potential risk indicator for colorectal cancer

Periodontal disease (PD) is a set of inflammatory conditions that affect t [...]

READ MORE

FDA Oks marketing of first AI device used to detect lesions during colonoscopy

The US Food and Drug Administration (FDA) recently approved the market [...]

READ MORE

Foods that Fight Cancer: Recipe Videos

We've posted some new recipe videos on our sister site, Foods that Fight C [...]

READ MORE

OICR Translational Research Conference

The Ontario Cancer Research Institute (OICR) held a conference on Tran [...]

READ MORE

Addressing cancer disparities in Canada

April is Diversity Month dedicated to celebrating and honouring all in [...]

READ MORE

The role of maintenance strategies in metastatic colorectal cancer

Results from a systematic review published in JAMA Oncology found that [...]

READ MORE

Swallowable capsule camera for home endoscopy

The National Health Service (NHS) in England will be conducting a stud [...]

READ MORE

Liquid biopsy for colorectal cancer could guide therapy for tumours

A study published in the Journal of Clinical Oncology Precision Oncology s [...]

READ MORE

ASCO names molecular profiling of gastrointestinal cancer “Advance of the Year”

Molecular profiling in gastrointestinal (GI) cancer has been named by [...]

READ MORE

The Importance of Self-care for Caregivers

Your physical, emotional and mental well-being are vital to your ability t [...]

READ MORE

Rates of eligible people missing timely cancer screenings: A Canadian analysis

New findings from the University of Alberta published in the Journal of th [...]

READ MORE

Postsurgical disease recurrence in stage I to III colorectal cancer may be predicted by ctDNA

Findings from a recent study presented at the 2021 Gastrointestinal Ca [...]

READ MORE

Survey Results: Never Too Young

Colorectal cancer is the second most diagnosed cancer in Canada. Twent [...]

READ MORE

Statins reduced risk of colorectal cancer in meta-analysis

10 December 2020Findings from a recent study showed that people who regula [...]

READ MORE

Hepatic Artery Infusion pumps in patients with colorectal cancer with liver metastases

22 December 2020 Hepatic Artery Infusion (HAI) chemotherapy is sometime [...]

READ MORE

“Test all patients with cancer”: 1 in 8 have inherited mutations

November 2020 Findings from a recent study conducted by the Mayo Clinic [...]

READ MORE

Rectal cancer management: do all patients need to undergo surgery?

The non-surgical management or  “watch-and-wait” approach for rectal c [...]

READ MORE

Palliative care for young adults is a growing reality in CRC

The incidence of colorectal cancer (CRC) is rising among young adults, who [...]

READ MORE

OPTIMISTICC Research Program sheds light on importance of gut microbiome in colorectal cancer development and treatment

Opportunity to Investigate the Microbiome’s Impact on Science and Treatmen [...]

READ MORE

Cancer Survivors Urgently Need Better Nutritional Support

New findings from a study conducted at the University of Sheffield in [...]

READ MORE

Intimacy and Colorectal Cancer

Sexuality and relationships during and after cancer is extremely impor [...]

READ MORE

World Metastatic Colorectal Cancer Day

Today, Wednesday September 30th, is World Metastatic Colorectal Cancer Day [...]

READ MORE

Optimal sequencing strategies in metastatic colorectal cancer

Dr. Heinz-Josef Lenz, MD, discusses optimal sequencing strategies for [...]

READ MORE

ESMO Virtual Congress 2020: Colorectal cancer highlights

The European Society for Medical Oncology ESMO Virtual Congress 2020 t [...]

READ MORE

Welcoming Our Newest CCC Ambassador, Jesse Fishman!

Jesse Fishman is a 17-year-old hockey player, currently playing for the Ki [...]

READ MORE

Do young diabetes patients need early CRC screening?

12 August 2020 Recent findings from a Swedish cohort study found that p [...]

READ MORE

Cancer Recurrence amid COVID-19: Robin’s Story

It was the day of the lockdown. My family doctor called. “The colorectal c [...]

READ MORE

Never Too Young Survey Launch

Fill out the survey! The world was shocked late last week as we learned a [...]

READ MORE

Gut bacteria found to modulate response to cancer immunotherapy

Previous data have shown that certain species of intestinal bacteria not o [...]

READ MORE

Your Seasonal Guide to Cancer-Fighting Foods

As we transition into autumn, take a moment to appreciate the seasonal pro [...]

READ MORE

Psychosocial support for patients with cancer during COVID-19

The COVID-19 pandemic has presented countless new challenges in cancer car [...]

READ MORE

COVID-19 NEWSLETTER

The COVID-19 pandemic situation is constantly evolving. Canada is slowly r [...]

READ MORE

CRC with peritoneal metastases: CRS-HIPEC refinements

Results of several new studies provide important perspectives on the use o [...]

READ MORE

Four actionable targets for metastatic colorectal cancer

In the past two years, findings from important clinical trials are shaping [...]

READ MORE

Patient Group Pathway Model to Accessing Cancer Clinical Trials and RWE Conference

Hold the Date! On behalf of Colorectal Cancer Canada (CCC), you are cordi [...]

READ MORE

Lynch Syndrome, Explained

What is Lynch Syndrome? Lynch syndrome is a genetically inherited conditi [...]

READ MORE

COVID-19 PATIENT SURVEY REPORT

Coronavirus has taken the world by storm since the beginning of 2020, and [...]

READ MORE

PUSH FOR YOUR TUSH VIRTUAL EVENT 2020

To ensure the health and safety of our participants, volunteers, staff and [...]

READ MORE

Gastrointestinal Highlights from last month’s ASCO 2020 Meeting

The American Society of Clinical Oncology (ASCO) held its annual meeting a [...]

READ MORE

How is colorectal cancer care changing in the era of COVID-19?

In just a few months, coronavirus (COVID-19) has transformed our lives. De [...]

READ MORE

Meatless for CRC prevention

It has been known for millennia that what we eat can be powerful medicine [...]

READ MORE

Immunotherapy treatment proves to be superior to chemotherapy for a specific subset of patients with mCRC

The last few decades have seen important advances in colorectal cancer tre [...]

READ MORE

Push For Your Tush volunteers spread the word

Co-leads of Push For Your Tush Ottawa share their connection to the cause [...]

READ MORE

2,700 VISITORS PASS THROUGH GIANT COLON TOUR AT THE SHERBROOKE HALF MARATHON

The Centre de recherche of the Centre hospitalier universitaire de Sherbro [...]

READ MORE

Colorectal cancer screening in Ontario is changing to the FIT

On June 24, 2019, colorectal cancer screening in Ontario is changing to th [...]

READ MORE

Remembering the “Father of Heredity Cancer” Dr. Henry Lynch

Today we remember Dr. Henry Lynch, esteemed researcher and father of hered [...]

READ MORE

Kicking cancer’s ass on the golf course

On Tuesday, July 16, Colorectal Cancer Canada (CCC) held our third annual [...]

READ MORE

Increasing rates of colon & rectal cancers in young people

Researchers with the World Health Organization confirm increased rates of [...]

READ MORE

CCC attends Early Age Onset Colorectal Cancer Summit in New York City

Last Thursday and Friday, Morgan Kennedy, CCC’s Never Too Young Program Ma [...]

READ MORE

Publication: Clinically meaningful survival benefit in refractory mCRC

Colorectal Cancer Canada (CCC) is proud to announce the publication of the [...]

READ MORE

Giant Colon visits University of Montreal Hospital Centre

Today, the Giant Colon Tour stopped at the University of Montreal Hospital [...]

READ MORE

CCC’s PUSH FOR YOUR TUSH SPARKS PARTNERSHIP WITH THE TORONTO PROFESSIONAL FIRE FIGHTERS ASSOCIATION

Most people do not know that cancer is the number one cause of death among [...]

READ MORE

March is Colorectal Cancer Awareness Month

March is Colorectal Cancer Awareness Month! Colorectal cancer may touch yo [...]

READ MORE

Sponsors

Sponsor Logo
Sponsor Logo
Sponsor Logo
Sponsor Logo
Sponsor Logo
Sponsor Logo
Sponsor Logo
Sponsor Logo
Sponsor Logo
Sponsor Logo
Sponsor Logo
Sponsor Logo
Sponsor Logo
Sponsor Logo
Sponsor Logo
Sponsor Logo
Sponsor Logo
Sponsor Logo
Sponsor Logo
Sponsor Logo
Sponsor Logo
Sponsor Logo
Sponsor Logo
Sponsor Logo