{"id":18814,"date":"2026-07-17T20:12:43","date_gmt":"2026-07-17T20:12:43","guid":{"rendered":"https:\/\/www.colorectalcancercanada.com\/non-classifiee\/using-ai-to-find-better-tumour-targets-for-car-t-cell-therapy\/"},"modified":"2026-07-17T20:14:19","modified_gmt":"2026-07-17T20:14:19","slug":"using-ai-to-find-better-tumour-targets-for-car-t-cell-therapy","status":"publish","type":"post","link":"https:\/\/www.colorectalcancercanada.com\/fr\/non-classifiee\/using-ai-to-find-better-tumour-targets-for-car-t-cell-therapy\/","title":{"rendered":"L\u2019intelligence artificielle au service de nouvelles cibles pour la th\u00e9rapie cellulaire CAR-T"},"content":{"rendered":"

La\u00a0th\u00e9rapie\u00a0\u00a0CAR\u00a0T-cell\u00a0a r\u00e9volutionn\u00e9 le traitement de certains cancers du sang. Cependant, son efficacit\u00e9 contre les tumeurs solides, tel que le cancer colorectal, demeure limit\u00e9. L\u2019un des principaux d\u00e9fis consiste \u00e0 r<\/span>\u00a0identifier des prot\u00e9ines pr\u00e9sentes uniquement, ou presque exclusivement, \u00e0 la surface des cellules canc\u00e9reuses et non sur les cellules saines,\u00a0<\/span>afin que le traitement puisse cibler le cancer de fa\u00e7on s\u00e9curitaire.<\/span>\u00a0<\/span><\/p>\n

Qu\u2019est-ce que la\u00a0th\u00e9rapie\u00a0\u00a0CAR\u00a0T-cell?\u00a0<\/strong><\/p>\n

La th\u00e9rapie\u00a0cellulaire\u00a0CAR-T\u00a0est une forme d\u2019immunoth\u00e9rapie\u00a0personnalis\u00e9e\u00a0qui\u00a0utilise les\u00a0propres\u00a0\u00a0cellules\u00a0immunitaires du patient pour combattre\u00a0son\u00a0\u00a0cancer. Les m\u00e9decins pr\u00e9l\u00e8vent des lymphocytes T (un type de globules blancs), les modifient g\u00e9n\u00e9tiquement en laboratoire afin qu\u2019ils puissent reconna\u00eetre une prot\u00e9ine sp\u00e9cifique pr\u00e9sente \u00e0 la surface des cellules canc\u00e9reuses, puis les r\u00e9injectent au patient. Une fois dans l\u2019organisme, ces cellules CAR-T modifi\u00e9es\u00a0peuvent\u00a0rep\u00e9rer,\u00a0attaquer\u00a0et\u00a0\u00a0d\u00e9truire\u00a0les cellules canc\u00e9reuses.<\/span>\u00a0<\/span><\/p>\n

Jusqu\u2019\u00e0 pr\u00e9sent, l\u2019identification de ces\u00a0proteines\u00a0cibles\u00a0r\u00e9tait\u00a0un processus long et complexe,\u00a0quii\u00a0n\u00e9cessitait\u00a0\u00a0l\u2019analyse\u00a0manuelle d\u2019une\u00a0grande\u00a0\u00a0quantit\u00e9\u00a0de donn\u00e9es biologiques. Dans une \u00e9tude r\u00e9cente, des chercheurs ont mis au point une nouvelle approche\u00a0utilisant\u00a0l\u2019intelligence artificielle (IA), notamment \u00e0 des mod\u00e8les de langage de grande taille (LLM),\u00a0afin\u00a0d\u2019acc\u00e9l\u00e9rer la recherche de cibles prometteuses pour\u00a0la th\u00e9rapie\u00a0CAR T-cell.<\/span>\u00a0<\/span><\/p>\n

L\u2019IA a analys\u00e9 des donn\u00e9es g\u00e9n\u00e9tiques\u00a0provenant de tissus canc\u00e9reux et de tissus sains, puis les a\u00a0combin\u00e9es\u00a0avec des informations\u00a0provenant\u00a0de bases de donn\u00e9es publiques afin d\u2019identifier\u00a0des\u00a0\u00a0prot\u00e9ines\u00a0cibles qui :<\/span>\u00a0<\/span><\/p>\n

Se\u00a0retrouveprincipalement\u00a0sur les cellules canc\u00e9reuses plut\u00f4t que sur les cellules saines;<\/span>\u00a0<\/span><\/p>\n

Se\u00a0retrouvent \u00e0 la surface des cellules, ce qui les rend accessibles aux cellules CAR-T;<\/span>\u00a0<\/span><\/p>\n

Pr\u00e9sentent\u00a0un potentiel consid\u00e9rable pour le d\u00e9veloppement de traitements \u00e0 la fois s\u00e9curitaires et efficaces.<\/span>\u00a0<\/span><\/p>\n

Gr\u00e2ce \u00e0 cette approche, les chercheurs ont identifi\u00e9 la prot\u00e9ine GPNMB comme\u00a0la cible la plus prometteuse. Ils ont ensuite\u00a0d\u00e9velopp\u00e9\u00a0une th\u00e9rapie\u00a0cellulaire\u00a0CAR-T dirig\u00e9e contre cette prot\u00e9ine. Les r\u00e9sultats obtenus en\u00a0laboraoire\u00a0\u00a0\u00a0ont\u00a0d\u00e9montr\u00e9\u00a0\u00a0que\u00a0cette\u00a0<\/span>th\u00e9rapie \u00e9tait capable de combattre\u00a0efficacement\u00a0<\/span>\u00a0des\u00a0mod\u00e8les\u00a0de cancer colorectal, de m\u00e9lanome et de leuc\u00e9mie.<\/span>\u00a0<\/span><\/p>\n

\u00c0 retenir\u00a0<\/strong><\/p>\n

En int\u00e9grant l\u2019intelligence artificielle au processus de recherche, il pourrait devenir possible d\u2019identifier plus rapidement de nouvelles cibles pour les\u00a0th\u00e9rapies\u00a0\u00a0CAR\u00a0T-cell. Cette avanc\u00e9e pourrait ouvrir la voie \u00e0 de nouvelles\u00a0approched\u2019immunoth\u00e9rapie\u00a0pour plusieurs types de cancers,\u00a0notamment\u00a0le cancer colorectal. Bien que les\u00a0r\u00e9sultats\u00a0\u00a0soient\u00a0prometteurs,\u00a0la\u00a0recherche\u00a0\u00a0demeure\u00a0\u00e0 un stade pr\u00e9clinique\u00a0tout de m\u00eame \u00e0 un stade pr\u00e9clinique\u00a0et\u00a0devra \u00eatre\u00a0appronfondi\u00a0par des\u00a0\u00e9tudes suppl\u00e9mentaires avant de pouvoir \u00eatre \u00e9valu\u00e9s chez les patients.<\/span>\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

La\u00a0th\u00e9rapie\u00a0\u00a0CAR\u00a0T-cell\u00a0a r\u00e9volutionn\u00e9 le traitement de certains cancers du sang. Cependant, son efficacit\u00e9 contre les tumeurs solides, tel que le cancer colorectal, demeure limit\u00e9. L\u2019un des principaux d\u00e9fis consiste \u00e0 r\u00a0identifier des prot\u00e9ines pr\u00e9sentes uniquement, ou presque exclusivement, \u00e0 la surface des cellules canc\u00e9reuses et non sur les cellules saines,\u00a0afin que …<\/a><\/p>\n","protected":false},"author":5,"featured_media":18908,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"footnotes":""},"categories":[12],"tags":[],"class_list":["post-18814","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-non-classifiee"],"_links":{"self":[{"href":"https:\/\/www.colorectalcancercanada.com\/fr\/wp-json\/wp\/v2\/posts\/18814","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.colorectalcancercanada.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.colorectalcancercanada.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.colorectalcancercanada.com\/fr\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/www.colorectalcancercanada.com\/fr\/wp-json\/wp\/v2\/comments?post=18814"}],"version-history":[{"count":1,"href":"https:\/\/www.colorectalcancercanada.com\/fr\/wp-json\/wp\/v2\/posts\/18814\/revisions"}],"predecessor-version":[{"id":18815,"href":"https:\/\/www.colorectalcancercanada.com\/fr\/wp-json\/wp\/v2\/posts\/18814\/revisions\/18815"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.colorectalcancercanada.com\/fr\/wp-json\/wp\/v2\/media\/18908"}],"wp:attachment":[{"href":"https:\/\/www.colorectalcancercanada.com\/fr\/wp-json\/wp\/v2\/media?parent=18814"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.colorectalcancercanada.com\/fr\/wp-json\/wp\/v2\/categories?post=18814"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.colorectalcancercanada.com\/fr\/wp-json\/wp\/v2\/tags?post=18814"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}