{"id":16796,"date":"2025-07-15T14:16:41","date_gmt":"2025-07-15T14:16:41","guid":{"rendered":"https:\/\/www.colorectalcancercanada.com\/?p=16796"},"modified":"2025-08-05T18:20:20","modified_gmt":"2025-08-05T18:20:20","slug":"lajustement-des-doses-de-chimiotherapie-a-base-doxaliplatine-pourrait-contribuer-a-reduire-les-lesions-nerveuses-dans-le-traitement-du-cancer-du-colon","status":"publish","type":"post","link":"https:\/\/www.colorectalcancercanada.com\/fr\/essais-cliniques\/lajustement-des-doses-de-chimiotherapie-a-base-doxaliplatine-pourrait-contribuer-a-reduire-les-lesions-nerveuses-dans-le-traitement-du-cancer-du-colon\/","title":{"rendered":"L&rsquo;ajustement des doses de chimioth\u00e9rapie \u00e0 base d&rsquo;oxaliplatine pourrait contribuer \u00e0 r\u00e9duire les l\u00e9sions nerveuses dans le traitement du cancer du c\u00f4lon"},"content":{"rendered":"<p><a href=\"https:\/\/ascopubs.org\/doi\/10.1200\/JCO-24-02754\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">Une \u00e9tude fran\u00e7aise r\u00e9cente <\/span><\/a><span data-contrast=\"auto\">sugg\u00e8re que l&rsquo;ajustement des doses de chimioth\u00e9rapie en fonction de la masse maigre (LBM) plut\u00f4t que de la surface corporelle standard pourrait r\u00e9duire les effets secondaires nerveux chez les personnes trait\u00e9es pour un cancer du c\u00f4lon de stade III.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Masse maigre : poids total du corps, \u00e0 l\u2019exclusion du poids de la graisse corporelle.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Surface corporelle standard : surface totale de la peau d&rsquo;un individu.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">L&rsquo;\u00e9tude\u202f:\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">L&rsquo;essai LEANOX a examin\u00e9 comment diff\u00e9rentes m\u00e9thodes de calcul de la dose d&rsquo;oxaliplatine (un m\u00e9dicament couramment utilis\u00e9 dans les protocoles de chimioth\u00e9rapie tels que le FOLFOX) affectaient les l\u00e9sions nerveuses, \u00e9galement appel\u00e9es neuropathie p\u00e9riph\u00e9rique induite par l&rsquo;oxaliplatine. Cet effet secondaire peut provoquer des picotements, des engourdissements, des br\u00fblures et des douleurs dans les mains et les pieds. Les effets peuvent persister pendant des mois, voire des ann\u00e9es apr\u00e8s la fin de la chimioth\u00e9rapie, et peuvent parfois \u00eatre permanents, ce qui a un impact n\u00e9gatif sur la qualit\u00e9 de vie.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Principaux r\u00e9sultats :\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"4\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Les personnes pr\u00e9sentant une masse maigre r\u00e9duite qui ont re\u00e7u une dose bas\u00e9e sur la LBM ont subi moins de l\u00e9sions nerveuses :<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"o\" data-font=\"Courier New\" data-listid=\"4\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:1440,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Courier New&quot;,&quot;469769242&quot;:[9675],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;o&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" data-aria-posinset=\"1\" data-aria-level=\"2\"><span data-contrast=\"auto\">67 % n&rsquo;ont pr\u00e9sent\u00e9 aucun probl\u00e8me nerveux significatif apr\u00e8s 6 cycles de chimioth\u00e9rapie en comparaison avec 42 % dans le groupe recevant la dose standard.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"4\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Le groupe trait\u00e9 en fonction de la LBM a \u00e9galement pr\u00e9sent\u00e9 :<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"o\" data-font=\"Courier New\" data-listid=\"4\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:1440,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Courier New&quot;,&quot;469769242&quot;:[9675],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;o&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" data-aria-posinset=\"1\" data-aria-level=\"2\"><span data-contrast=\"auto\">moins de r\u00e9ductions de dose en raison d\u2019effets secondaires,<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"o\" data-font=\"Courier New\" data-listid=\"4\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:1440,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Courier New&quot;,&quot;469769242&quot;:[9675],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;o&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" data-aria-posinset=\"2\" data-aria-level=\"2\"><span data-contrast=\"auto\">une meilleure qualit\u00e9 de vie et<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"o\" data-font=\"Courier New\" data-listid=\"4\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:1440,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Courier New&quot;,&quot;469769242&quot;:[9675],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;o&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" data-aria-posinset=\"3\" data-aria-level=\"2\"><span data-contrast=\"auto\">un d\u00e9lai plus long avant l&rsquo;apparition des sympt\u00f4mes nerveux.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"4\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"auto\">Les r\u00e9sultats en mati\u00e8re de cancer (survie sans r\u00e9cidive et survie globale \u00e0 3 ans) \u00e9taient similaires dans tous les groupes, ce qui signifie que l&rsquo;ajustement de la dose d&rsquo;oxaliplatine n&rsquo;a pas r\u00e9duit l&rsquo;efficacit\u00e9 du traitement.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><span data-contrast=\"auto\">Message \u00e0 retenir :<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Cette \u00e9tude sugg\u00e8re que chez les patients pr\u00e9sentant une masse maigre faible, l&rsquo;ajustement des doses d&rsquo;oxaliplatine en fonction de la LBM peut r\u00e9duire les effets secondaires sans compromettre la survie. Cela pourrait conduire \u00e0 une chimioth\u00e9rapie plus personnalis\u00e9e et mieux tol\u00e9r\u00e9e pour les personnes atteintes d&rsquo;un cancer du c\u00f4lon de stade III.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Une \u00e9tude fran\u00e7aise r\u00e9cente sugg\u00e8re que l&rsquo;ajustement des doses de chimioth\u00e9rapie en fonction de la masse maigre (LBM) plut\u00f4t que de la surface corporelle standard pourrait r\u00e9duire les effets secondaires nerveux chez les personnes trait\u00e9es pour un cancer du c\u00f4lon de stade III.\u00a0 Masse maigre : poids total du corps, <a href=\"https:\/\/www.colorectalcancercanada.com\/fr\/essais-cliniques\/lajustement-des-doses-de-chimiotherapie-a-base-doxaliplatine-pourrait-contribuer-a-reduire-les-lesions-nerveuses-dans-le-traitement-du-cancer-du-colon\/\">&#8230;<\/a><\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57,98],"tags":[],"class_list":["post-16796","post","type-post","status-publish","format-standard","hentry","category-essais-cliniques","category-research-updates-fr"],"_links":{"self":[{"href":"https:\/\/www.colorectalcancercanada.com\/fr\/wp-json\/wp\/v2\/posts\/16796","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.colorectalcancercanada.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.colorectalcancercanada.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.colorectalcancercanada.com\/fr\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/www.colorectalcancercanada.com\/fr\/wp-json\/wp\/v2\/comments?post=16796"}],"version-history":[{"count":0,"href":"https:\/\/www.colorectalcancercanada.com\/fr\/wp-json\/wp\/v2\/posts\/16796\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.colorectalcancercanada.com\/fr\/wp-json\/wp\/v2\/media?parent=16796"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.colorectalcancercanada.com\/fr\/wp-json\/wp\/v2\/categories?post=16796"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.colorectalcancercanada.com\/fr\/wp-json\/wp\/v2\/tags?post=16796"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}