{"id":18236,"date":"2026-04-01T13:37:38","date_gmt":"2026-04-01T13:37:38","guid":{"rendered":"https:\/\/www.colorectalcancercanada.com\/?post_type=drug&#038;p=18236"},"modified":"2026-04-08T16:48:44","modified_gmt":"2026-04-08T16:48:44","slug":"leucovorin","status":"publish","type":"drug","link":"https:\/\/www.colorectalcancercanada.com\/fr\/drug\/leucovorin\/","title":{"rendered":"Leucovorin"},"content":{"rendered":"<p><strong>Indication :<\/strong><\/p>\n<p>Indiqu\u00e9 comme agent modulateur utilis\u00e9 en association avec une chimioth\u00e9rapie \u00e0 base de fluorouracile dans le traitement du cancer colorectal, tant en traitement adjuvant qu\u2019en cas de m\u00e9tastases. Elle est le plus souvent administr\u00e9e avec le 5-fluorouracile dans le cadre de sch\u00e9mas th\u00e9rapeutiques tels que FOLFOX et FOLFIRI afin de renforcer l&rsquo;activit\u00e9 antitumorale du fluorouracile dans le traitement du cancer du c\u00f4lon de stade III apr\u00e8s r\u00e9section chirurgicale et du cancer colorectal m\u00e9tastatique (mCRC). La leucovorine n&rsquo;a pas d&rsquo;activit\u00e9 anticanc\u00e9reuse ind\u00e9pendante dans le cancer colorectal, mais elle est un composant essentiel des sch\u00e9mas th\u00e9rapeutiques de chimioth\u00e9rapie combin\u00e9e standard largement utilis\u00e9s au Canada.<\/p>\n","protected":false},"template":"","crc_subtype":[401],"drug_stage":[416,417,402],"therapy_line":[418],"health_canada_approval":[404],"cda_review":[],"cda_recommendation":[],"inesss_review":[],"inesss_recommendation":[],"pcpa_status":[],"public_reimbursement":[411,410,454,450,451,414,457,453,413,412,452,456,455],"class_list":["post-18236","drug","type-drug","status-publish","hentry","crc_subtype-none-fr","drug_stage-ii-fr","drug_stage-iii-fr","drug_stage-iv-fr","therapy_line-premiere-ligne","health_canada_approval-approved-fr","public_reimbursement-alberta-fr","public_reimbursement-colombie-britannique-fr","public_reimbursement-i-p-e","public_reimbursement-manitoba-fr","public_reimbursement-n-b","public_reimbursement-ns-fr","public_reimbursement-nt","public_reimbursement-on","public_reimbursement-qc-fr","public_reimbursement-sk-fr","public_reimbursement-t-n-l","public_reimbursement-t-n-o","public_reimbursement-yn"],"_links":{"self":[{"href":"https:\/\/www.colorectalcancercanada.com\/fr\/wp-json\/wp\/v2\/drug\/18236","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.colorectalcancercanada.com\/fr\/wp-json\/wp\/v2\/drug"}],"about":[{"href":"https:\/\/www.colorectalcancercanada.com\/fr\/wp-json\/wp\/v2\/types\/drug"}],"wp:attachment":[{"href":"https:\/\/www.colorectalcancercanada.com\/fr\/wp-json\/wp\/v2\/media?parent=18236"}],"wp:term":[{"taxonomy":"crc_subtype","embeddable":true,"href":"https:\/\/www.colorectalcancercanada.com\/fr\/wp-json\/wp\/v2\/crc_subtype?post=18236"},{"taxonomy":"drug_stage","embeddable":true,"href":"https:\/\/www.colorectalcancercanada.com\/fr\/wp-json\/wp\/v2\/drug_stage?post=18236"},{"taxonomy":"therapy_line","embeddable":true,"href":"https:\/\/www.colorectalcancercanada.com\/fr\/wp-json\/wp\/v2\/therapy_line?post=18236"},{"taxonomy":"health_canada_approval","embeddable":true,"href":"https:\/\/www.colorectalcancercanada.com\/fr\/wp-json\/wp\/v2\/health_canada_approval?post=18236"},{"taxonomy":"cda_review","embeddable":true,"href":"https:\/\/www.colorectalcancercanada.com\/fr\/wp-json\/wp\/v2\/cda_review?post=18236"},{"taxonomy":"cda_recommendation","embeddable":true,"href":"https:\/\/www.colorectalcancercanada.com\/fr\/wp-json\/wp\/v2\/cda_recommendation?post=18236"},{"taxonomy":"inesss_review","embeddable":true,"href":"https:\/\/www.colorectalcancercanada.com\/fr\/wp-json\/wp\/v2\/inesss_review?post=18236"},{"taxonomy":"inesss_recommendation","embeddable":true,"href":"https:\/\/www.colorectalcancercanada.com\/fr\/wp-json\/wp\/v2\/inesss_recommendation?post=18236"},{"taxonomy":"pcpa_status","embeddable":true,"href":"https:\/\/www.colorectalcancercanada.com\/fr\/wp-json\/wp\/v2\/pcpa_status?post=18236"},{"taxonomy":"public_reimbursement","embeddable":true,"href":"https:\/\/www.colorectalcancercanada.com\/fr\/wp-json\/wp\/v2\/public_reimbursement?post=18236"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}